We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.
Salary: Research Assistant: £28,331 - £30.046 per annum
Research Associate: £30,942 - £36,914 per annum
Closing Date: 23 November 2020
This is an exciting opportunity to work on a British Heart Foundation programme grant to study the development and disease of the heart valves. You will work on a project to understand how the heart valves develop in the zebrafish and how abnormalities in shared mammalian processes lead to human congenital valve defects. You will take data from genetic screens to investigate how patient variants can result in common malformations such as bicuspid aortic valve and develop assays for screening new variants for pathogenicity. The role will allow you to apply and develop your interest in developmental biology, cell biology, and disease modelling (CRISPR in zebrafish) to the field of congenital heart defects. You will enhance your expertise in imaging, image analysis and molecular genetics.
To join a team studying the developmental genetic basis of human valve disorders. You will use a wide variety of molecular, protein and imaging techniques to achieve this, using zebrafish as a model system. You will be responsible for planning and carrying out the zebrafish experiments that form an integral part of the investigations carried out by the research team.
Contribute to and actively participate with other researchers within the groups collaborative research projects as outlined above. The main research duties as currently envisaged are:
Work in a professional and effective manner with the principle investigators (Prof Deborah Henderson and Dr Bill Chaudhry) and the laboratory manager, as well as other team members.
Under the guidance of the laboratory manager (who will manage the zebrafish colonies), effectively utilise zebrafish for research goals
Under the leadership of the laboratory manager, to ensure the smooth running of the laboratory. This may involve contributing to the planning of equipment and material needs, including maintaining laboratory stocks of chemicals, media and other consumables. Determine requirements and initiate orders, within specified laboratory ordering procedures, or help maintain reagent databases
Undertake and provide training in experimental methods or use of specialised equipment in an effective and timely manner to academic, technical and research staff. Consult with principle investigators regarding developing new or improved methods for experimental systems and create effective protocols
Supervise undergraduate and post graduate students, as directed by principle investigators or laboratory manager, whilst maintaining progress on other activities
Perform risk assessments and maintain safety laboratory records (e.g. COSHH, BIOCOSHH, and other regulations) in consultation with principle investigators or laboratory manager
Knowledge, Skills and Experience
• Expertise in zebrafish embryology, anatomy and dissection
• Experience of creating CRISPR mutants in zebrafish and designing appropriate genotyping assays
• Expertise in standard zebrafish histopathology skills including embedding and sectioning in resin
• Expertise in in situ hybridisation and immuno-histochemistry in zebrafish embryos
• Expertise in confocal and epifluorescence imaging of zebrafish embryos
• Hold, or have held, a personal license to carry out research using zebrafish
• Excellent knowledge of the zebrafish literature and ability to integrate knowledge of different areas of research to come up with testable hypotheses
• Excellent Information technology and computing skills
• Publication of work in peer-reviewed journals
• Presentation of work at scientific meetings
• Sperm freezing in zebrafish (Desirable)
Attributes and Behaviour
• Team-working skills
• Ability to plan and organise own work
• Responsible attitude to work
• Attention to detail
• Capacity for original thought
• Excellent oral communication and writing skills
• Willingness to undertake work outside of normal working hours
• Good BSc degree in a biological science
• Completion (Associate level) (or current submission for Assistant level) a PhD in the area of embryology or molecular biology or genetics
Newcastle University is committed to being a fully inclusive Global University which actively recruits, supports and retains staff from all sectors of society. We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the communities they represent. We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices.
The University holds a silver Athena SWAN award in recognition of our good employment practices for the advancement of gender equality. The University also holds the HR Excellence in Research award for our work to support the career development of our researchers, and is a member of the Euraxess initiative supporting researchers in Europe.
Please be advised that due to the minimum salary thresholds imposed by the UKVI, this post may not qualify for University sponsorship under Tier 2 of the points based system.
Requisition ID: 5338
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